Broadway audiences have become inured to ------- and so ------- to be pleased as to make their ready ovatIons meaningless as an indicator of the quality of the production before them.
Becoming inured to something means getting accustomed to it (in most cases a bad thing! ) → thus, blank(i) is a negative word.
Now, looking at 2^{nd} half of the sentence we have
Now, generally ovations (cheering!!) is a sign of something being good/enjoyable but here this has become meaningless : means they’re clapping at everything doesn’t matter if its not even good! : → They have become hopeless or are a lost cause!
Hence, we’re looking for -ve words for both the blanks!
