How to solve this TC question?

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I’ve tried to solve this twice with the TC strategies but all options seem too close, I got it wrong twice.

Isolated and lonely = -ve → So , blank(1) will be -ve as well.
Now, what people want do with negative situations → Flee/escape them.

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Okay so here, it can never be permanen/irreparable because these conditions are never permanent and can be rectified?

Yeah, first of all irreparable means impossible to get out of the situation and second, avoid will also not fit blank(ii) as according to the question the people are already in the situation so they can’t avoid it now , they either have to accept it or escape it

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Yes, thank you!