Offcial Guide Verbal Question

In his initial works, the playwright made physical disease (i) factor in the
action; from this, his early critics inferred that he had a predilection for focusing
on (ii) subject matter

Blank (i) Blank (ii)
A a pivotal D recondite
B a nonexistent E uncomplicated
C an obscure F morbid
Can anyone explain this question to me?

i have the same doubt.